Abstract
Following acute intracerebroventricular injections of 1 ng of apamin and chronic apamin infusion (0.4 ng/ μl, 0.5 μl/h, 14 days), the rat brains exhibited bilateral damage only in the cerebellum. The argyrophilic cells were Purkinje cells in copula pyramis, flocculus, paraflocculus, and paramedian lobules. These data demonstrate that the inactivation of small conductance Ca 2+-activated K + channels by apamin induces a non-limbic neurodegeneration.
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