Abstract
The number of acute organ failures has been shown to be an important determinant of prognosis in critically ill cancer patients admitted to an ICU [1]. Although the SOFA score is useful in analyzing the number and the severity of acute organ failures related to ICU mortality, it is not validated to predict outcomes in the ICU. On the other hand, general prognostic models have failed to accurately predict outcomes in the oncologic population [2,3]. Given this, we propose to analyze the ability of the SOFA score compared with the APACHE II score in predicting ICU and inhospital mortality in oncologic patients.
Highlights
Clinical evidence suggests that bacterial translocation (BT) may not be the primary cause in the development of sepsis and multiple organ dysfunction
In previous work we demonstrated that platelet-derived attributed to bacterial translocation (BT), and the aggravation of microparticles (MP) can induce endothelial and vascular smooth sepsis is related to the increased vascular permeability state that muscle cell apoptosis in septic patients through NADPH oxidase- potentates the BT index
The aim of this study is to evaluate the effects of hypertonic saline (HSS) 7.5% and lactated Ringer’s (LR) solutions on intestinal BT in rats that underwent intestinal obstruction and ischaemia (IO)
Summary
Clinical evidence suggests that bacterial translocation (BT) may not be the primary cause in the development of sepsis and multiple organ dysfunction. The evolution of intensive care and its results related to the survival of very critically ill patients produce a group of survivors characterized by complex co-morbidities and prolonged dependence on mechanical ventilation (more than 21 days). Methods A prospective, nonrandomized, observational and comparative study that compares effects on PPV of the VC with another three PC ventilatory settings applied in sedated and mechanically ventilated critically ill patients with an arterial catheter in place. The APACHE II score (26.1 ± 9.5 vs 17.7 ± 6.0, P = 0.000), mean SOFA score (10.55 ± 3.41 vs 3.52 ± 2.29, P < 0.001), use of a central catheter (87.5% vs 60.7%, P = 0.001), dialysis (21.4% vs 5.4%, P = 0.013), mechanical ventilation (91.1% vs 35.7%, P < 0.001) and presence of septic shock (32.1% vs 8.9%, P = 0.002) were associated with worse prognosis. Several complications are possible, making it necessary to provide an immediate, specialized, postoperatory intensive care treatment
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