AOSOP2 Association of caveolin-1 genotypes with susceptibility to oral cancer in Taiwan

Abstract

Background Caveolin-1 (Cav-1), a proposed candidate tumour suppressor, plays a regulatory role in several signalling pathways. The aim in this hospital-based case–control study was to investigate the association of Cav-1 polymorphisms with risk of oral cancer in a central Taiwanese population. Methods Six hundred patients with oral cancer and 620 age-matched and sex-matched healthy controls were genotyped and analysed by use of polymerase chain reaction–restriction fragment length polymorphism. Findings There were significant differences between oral cancer and control groups in the distributions of Cav-1 genotypes ( p = 1.7 × 10 –18 and 2.6 × 10 –4 ) and allelic frequencies in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms ( p = 3.3 × 10 –19 and 9.5 × 10 –6 , respectively). In the combined genotype analysis, individuals who had GG/AT or GG/AA at Cav-1 G14713A or T29107A had a 0.72-fold (95% confidence interval = 0.52–0.99) decreased risk of oral cancer compared with those with GG/TT, whereas any other combinations were associated with increased risk. The presence of metastasis was also correlated with both Cav-1 G14713A AA and C-1 T29107A TT genotypes. Interpretation Cav-1 seems to have a role in oral cancer; the A allele of Cav-1 G14713A is associated with increased risk, A allele of Cav-1 T29107A is protective, and AA/TT on these two polymorphisms might be the combined genotype that is associated with the most risk for the development of oral cancer. These variants could be novel risk markers for early detection and prediction of distant metastasis. The authors declared no conflicts of interest.