Abstract
As vascular calcification is common in kidney transplant candidates, aorto-iliac vessel imaging is performed for surgical planning. The aim of the present study was to investigate whether a novel non-contrast enhanced computed tomography-based quantification technique for aorto-iliac calcification can be used for cardiovascular risk stratification prior to kidney transplantation. In this dual-center cohort study, we measured the aorto-iliac calcium score (CaScore) of 547 patients within three years prior to transplantation (2005–2018). During a median (interquartile range) follow-up of 3.1 (1.4, 5.2) years after transplantation, 80 (14.7%) patients died, of which 32 (40.0%) died due to cardiovascular causes, and 84 (15.5%) patients had a cardiovascular event. Kaplan-Meier survival curves showed significant differences between the CaScore tertiles for cumulative overall-survival (Log-rank test p < 0.0001), cardiovascular survival (p < 0.0001), and cardiovascular event-free survival (p < 0.001). In multivariable Cox regression, the aorto-iliac CaScore was associated with all-cause mortality (hazard ratio 1.53, 95%CI 1.14–2.06, p = 0.005), cardiovascular mortality (2.04, 1.20–3.45, p = 0.008), and cardiovascular events (1.35, 1.01–1.80, p = 0.042). These independent associations of the aorto-iliac CaScore with the outcome measures can improve the identification of patients at risk for (cardiovascular) death and those who could potentially benefit from stringent cardiovascular monitoring to improve their prognosis after transplantation.
Highlights
Kidney transplantation improves survival of patients with end-stage renal disease (ESRD) and reduces cardiovascular disease burden [1,2]
Multidisciplinary evaluation, including consultation of a vascular surgeon, to evaluate the cardiovascular status of kidney transplant candidates could improve the identification of patients at risk for death and those who could potentially benefit from interventions to improve their prognosis after transplantation [5,6,7]
This dual-center cohort consisted of 547 kidney transplant recipients, with a mean time between computed tomography (CT) and transplantation of 0.91 (0.72) years
Summary
Kidney transplantation improves survival of patients with end-stage renal disease (ESRD) and reduces cardiovascular disease burden [1,2]. Despite the improved prognosis after transplantation, patients remain vulnerable, with cardiovascular disease as the leading cause of death [2,3]. Multidisciplinary evaluation, including consultation of a vascular surgeon, to evaluate the cardiovascular status of kidney transplant candidates could improve the identification of patients at risk for (cardiovascular) death and those who could potentially benefit from interventions to improve their prognosis after transplantation [5,6,7]. As ESRD accelerates vascular calcification and kidney transplantation incompletely decreases this acceleration, cardiovascular risk stratification is not always straightforward in this population [10,11]
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