Abstract
Aortic valve stenosis remains the most frequent structural heart disease, especially in the elderly. During the last decade, we noticed an important consideration and a huge number of publications related to the medical and surgical treatment of this disease. However, the molecular aspect of this degenerative issue has also been more widely studied recently. As evidenced in oncologic but also cardiac research fields, the emergence of microRNAs in the molecular screening and follow-up makes them potential biomarkers in the future, for the diagnosis, follow-up and treatment of aortic stenosis. Herein, we present a review on the implication of microRNAs in the aortic valve disease management. After listing and describing the main miRNAs of interest in the field, we provide an outline to develop miRNAs as innovative biomarkers and innovative therapeutic strategies, and describe a groundbreaking pre-clinical study using inhibitors of miR-34a in a pre-clinical model of aortic valve stenosis.
Highlights
During the last decade, the management of aortic valve stenosis was one of the most mediatized items in cardiovascular medical and surgical meetings around the world
We report a general review on the recent advances in the clinical and molecular aortic stenosis management according to the recent literature
The process from the isolation and identification of miRNAs in any disease is resumed in Fig. 2, with the different steps leading to the clinical application of miRNAs as diagnosis or prognosis biomarkers and evolving to the development of innovative treatment (Fig. 2)
Summary
The management of aortic valve stenosis was one of the most mediatized items in cardiovascular medical and surgical meetings around the world. Researchers started to be more interested in the molecular aspect of the calcification process [4], looking for a specific biomarker able to predict calcification progression or severity, in order to prevent it or to improve the minimally invasive follow-up. These molecular interests were accelerated and widened with the emerging of the knowledges on the effect of noncoding RNA in the regulation of cellular and molecular processes, implicated in a large number of diseases. We report a general review on the recent advances in the clinical and molecular aortic stenosis management according to the recent literature
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