Abstract
Arterial stiffening is related to an intricate interplay between aging and other cardiovascular risk factors. The aortic arch accounts for most of the vascular buffering function and is primarily involved in arterial stiffening. MRI has been used to noninvasively measure strain, distensibility, and pulse wave velocity of the ascending aorta. We report aortic size and stiffness changes over mid to late adulthood in longitudinal comparisons with MRI over a 10-year period in the MESA cohort.
Highlights
Changes in the human cardiovascular system are an important aspect of aging
We report aortic size and stiffness changes over mid to late adulthood in longitudinal comparisons with MRI over a 10-year period in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort
Aortic stiffness can be described by changes in aortic dimensions such as strain, as well as, combined with pressure, distensibility
Summary
Changes in the human cardiovascular system are an important aspect of aging. Arterial stiffness, a major determinant of increased systolic pulse pressure, is associated with aging and with the incidence of stroke, ischemic heart disease and heart failure. Aortic stiffness can be described by changes in aortic dimensions such as strain (proportional change of aortic area to the minimum area), as well as, combined with pressure, distensibility (relative dimensional change related to changes in local pressure). Another approach to aortic stiffness is the measurement of pulse wave velocity (PWV). While these changes with advancing age have been established in cross-sectional studies, few longitudinal data exist on the evolution of aortic biomechanical parameters. The aims of this study are to assess the longitudinal changes in central aortic size and stiffness measured with MRI over a 10-year period in the MESA cohort
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