Abstract

New capillaries arise from the pre-existing vasculature (arterioles, venules and capillaries) through a series of steps that involve the endothelium and the surrounding extracellular matrix (ECM). The principal morphological events involved in angiogenesis were described in the 1940s. Electron microscopic studies performed over 20 years later have confirmed these initial observations and added further detailed information [1–3].

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