Abstract
Summary The cholesteryl ester synthesizing (S) and hydrolysing (H) activities of rabbit aorta have been assayed in rabbits fed an atherogenic regimen (2% cholesterol in 6% corn oil). Both synthesis and hydrolysis of cholesteryl esters increase over control levels, but the increase in synthetase activity is much greater than that of hydrolase activity. The S/H ratio is sharply increased after 5–7 days on the atherogenic diet, a time when serum and liver cholesterol levels have risen but no atheromata are grossly visible.
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