Abstract
AOP Report: Inhibition of Chitin Synthase 1 Leading to Increased Mortality in Arthropods.
Highlights
AND BACKGROUND: Arthropods rely on the synthesis of chitin to complete their life cycles (Merzendorfer 2011)
These effects are observed in arthropods following molting, which fail to survive subsequent molts (Arakawa et al 2008; Chen et al 2008) or animals being stuck in their exuviae (Wang et al 2019) and dying as a result of insufficient food or oxygen intake (Camp et al 2014; Song et al 2017a)
The present adverse outcome pathway (AOP) (Figure 1 and Textbox 1) describes the potential causal events initiated by inhibition of the enzyme chitin synthase isoform 1 (CHS‐1) (MIE, event 1522), leading to increased mortality via the key events (KEs) of decreased cuticular chitin content and increased premature molting
Summary
Pathways and Predictions articles are summaries of multi‐process biological responses to chemicals described by extensive datasets. Adverse outcome pathways (AOPs) are one example of this where comprehensive compilations of concepts and evidence comprising a given AOP can be obtained from an open‐source AOP Wiki (aopwiki.org). AOP Report: Inhibition of Chitin Synthase 1 Leading to Increased Mortality in Arthropods. ASection of Ecotoxicology and Risk Assessment, Norwegian Institute for Water Research, Oslo, Norway bFaculty of Environmental Sciences and Natural Resource Management, Norwegian University of Life Sciences, Ås, Norway cCentre for Environmental Radioactivity, Norwegian University of Life Sciences, Ås, Norway
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