Abstract
Despite decades of research with humans, the biological mechanisms that motivate an individual to help others remain poorly understood. In order to investigate the roots of pro-sociality in mammals, we established the helping behavior test, a paradigm in which rats are faced with a conspecific trapped in a restrainer that can only be opened from the outside. Over the course of repeated test sessions, rats exposed to a trapped cagemate learn to open the door to the restrainer, thereby helping the trapped rat to escape (Ben-Ami Bartal et al., 2011). The discovery of this natural behavior provides a unique opportunity to probe the motivation of rodent helping behavior, leading to a deeper understanding of biological influences on human pro-sociality. To determine if an affective response motivates door-opening, rats receiving midazolam, a benzodiazepine anxiolytic, were tested in the helping behavior test. Midazolam-treated rats showed less helping behavior than saline-treated rats or rats receiving no injection. Yet, midazolam-treated rats opened a restrainer containing chocolate, highlighting the socially specific effects of the anxiolytic. To determine if midazolam interferes with helping through a sympatholytic effect, the peripherally restricted beta-adrenergic receptor antagonist nadolol was administered; nadolol did not interfere with helping. The corticosterone response of rats exposed to a trapped cagemate was measured and compared to the rats’ subsequent helping behavior. Rats with the greatest corticosterone responses showed the least helping behavior and those with the smallest responses showed the most consistent helping at the shortest latency. These results are discussed in terms of their implications for the interaction between stress and pro-social behavior. Finally, we observed that door-opening appeared to be reinforcing. A novel analytical tool was designed to interrogate the pattern of door-opening for signs that a rat’s behavior on one session influenced his behavior on the next session. Results suggest that helping a trapped rat has a greater motivational value than does chocolate. In sum, this series of experiments clearly demonstrates the fundamental role of affect in motivating pro-social behavior in rodents and the need for a helper to resonate with the affect of a victim.
Highlights
Helping refers to actions that intentionally benefit others (Cronin, 2012)
The results show that there is a significant correlation between HPA reactivity to vicarious distress and door-opening latency, suggesting that HPA reactivity may antagonize helping
This study demonstrates that the release of a trapped conspecific requires affective processing that is blocked by the benzodiazepine anxiolytic MDZ
Summary
Helping refers to actions that intentionally benefit others (Cronin, 2012). In humans, helping is often motivated by an empathic response to the distress and pain of others. It is very hard to predict when helping will occur, and why some situations fail to elicit an empathic response. Anxiolytics Impair Rat Helping Behavior in pro-social behavior. It is imperative to parse out the biological mechanisms that give rise to an emotional response to the distress of others, a task that has seen only partial success with human studies. An animal model of pro-social behavior is crucial for investigating the biological cascade of events that occur in the moments between the observation of distress and the decision to act for the benefit of others
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