ANXIOLYTIC ACTION OF OROSTACHYS SPINOSA DRY EXTRACT

Abstract

The study purpose: to evaluate the anxiolytic effect of the Orostachys spinosa dry extract. Material and methods. The studies were carried out on Wistar rats. An aqueous solution of the O. spinosa extract at doses of 50, 100 and 200 mg/kg was administered to the experimental groups animals for 14 days prior to testing. The anxiolytic effect of the O. spinosa extract was evaluated in the tests: "open field", "elevated plus maze", "light/dark chamber", "unmotivated aggression" and "conflict situation" according to Vogel. Results. It was found that the O. spinosa extract at doses of 100 and 200 mg/kg increases the vertical, horizontal activity and the index of the mink reflex in the "open field"; the entries number and the time into the open arms in the elevated plus maze; the transitions number and the time spent in the light section in the "light/dark chamber". Under conditions of "punishable behavior", the O. spinosa extract at a dose of 100 mg/kg exhibits anti-aggressive and anxiolytic effects. The studied extract reduces the anxiogenic effects of bicuculline and picrotoxin in the Vogel test. Conclusion. The O. spinosa dry extract has an anxiolytic effect, which is due to its stimulating effect on the GABAergic system.