Abstract
Objective: Toevaluate the anxiogenic effect on acute administration of gemifloxacin in wistar albino rats. Methods: Elevated plus maze and open field test models were used. Rats were divided into four groups (n=6). All drugs used in the study were freshly prepared and administered orally, sixty minutes prior to the experiment. Group I (Control) received 10 mL distilled water, Group II received moxifloxacin (36 mg/kg), Groups III and IV received test drug, gemifloxacinat 50 and 100 mg/kg body weight respectively.The Results were analyzed using one way ANOVA followed by Dunnett’s post hoc test. Results: There wasa statistically significant (p<0.05) decrease in total arm entries in elevated plus maze model compared to control. In open field test, the time spent in central squares was decreased whereas in peripheral squares was increased compared to control. Conclusion: The present studyshowedanxiogenic activity of gemifloxacin in wistar albino rats.
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