Abstract
This study investigated risk assessment and anxiolytic/anxiogenic drug effects in “low brain angiotensinogen” transgenic rats (TGR) in comparison to wild-type Sprague–Dawley rats (SD) in the canopy test of anxiety-related behaviour. TGR showed a higher frequency of the risk assessment behaviour as indicated by performance of stretched attend posture (SAP) compared to SD. Diazepam (0.25 mg/kg) reduced SAP in both strains, whereas FG-7142 had no significant effect. The 5-HT 1B/2C agonist mCPP (0.5–2 mg/kg) reduced SAP in both strains. Diazepam (0.25–1 mg/kg) increased head dips and decreased the time spent under the canopy in SD rats. There were significant anxiogenic effects of both FG-7142 (3–6 mg/kg) and mCPP (0.5–2 mg/kg) on these parameters for SD but not TGR. Diazepam (1 mg/kg) increased the number of entries into the open zone in both strains. mCPP reduced this parameter in SD (2 mg/kg) and TGR (0.5–2 mg/kg). FG-7142 had a similar effect in SD (3–6 mg/kg) and TGR (6 mg/kg). This study showed a significant transgenic effect on SAP. The increased number of SAP seen in TGR could be reduced with diazepam. Although both FG-7142 and mCPP are generally anxiogenic, no significant effects of FG-7142 on SAP were observed and mCPP even reduced SAP.
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