Anxiety and depression severity in neuropsychiatric SLE are associated with perfusion and functional connectivity changes of the frontolimbic neural circuit: a resting-state f(unctional) MRI study

Despina Antypa,Prodromos Sidiropoulos,Antonis Fanouriakis,Eleftherios Kavroulakis,Nicholas J Simos,Efrosini Papadaki,George Bertsias,Dimitrios Boumpas

doi:10.1136/lupus-2020-000473

Anxiety and depression severity in neuropsychiatric SLE are associated with perfusion and functional connectivity changes of the frontolimbic neural circuit: a resting-state f(unctional) MRI study

Despina Antypa, Prodromos Sidiropoulos + Show 6 more

Open Access

https://doi.org/10.1136/lupus-2020-000473

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Journal: Lupus Science & Medicine	Publication Date: Apr 1, 2021
Citations: 10	License type: open-access

Affiliation: University of Crete, University Hospital of Heraklion, University General Hospital Attikon, Technical University of Crete, Foundation for Research and Technology Hellas, Biomedical Research Foundation of the Academy of Athens, National and Kapodistrian University of Athens

#Neuropsychiatric SLE #Anxiety Symptoms + Show 8 more

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Abstract

ObjectiveTo examine the hypothesis that perfusion and functional connectivity disturbances in brain areas implicated in emotional processing are linked to emotion-related symptoms in neuropsychiatric SLE (NPSLE).MethodsResting-state fMRI (rs-fMRI) was performed...

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