Abstract
In three dogs, each prepared with an innervated antral pouch, vagally denervated fundic pouch, and a gastric fistula of the main stomach, gastric secretion was stimulated by intravenous infusion of a submaximal dose of pentagastrin. Antral acidification at pH 1.0 did not inhibit the acid secretory response of the fundic pouch during tests in which the gastric fistula was closed. When the gastric fistula was opened, acidification did not affect the acid secretion of either the denervated fundic pouch or innervated main stomach. Diversion of acid from the duodenum did not influence the over-all level of acid secretion from the fundic pouch. Antral acidification did inhibit the acid secretory response of the fundic pouch after ingestion of a meat meal (25 gm per kg of body weight), although pepsin outputs remained unchanged. The results provide no support for the existence of either an antral inhibitory hormone or inhibitory neural reflex active against pentagastrin-stimulated gastric secretion in the dog. Antral inhibition of gastric secretion is the result of a diminished release or formation of endogenous gastrin.
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