Abstract
The free radical scavenging activity of extracts prepared from Myelophycus simplex was evaluated by using an ESR spectrometer. For this study, Myelophycus simplex was 70% ethanol extraction was performed. Myelophycus simplex extracts scavenged DPPH, hydroxyl, superoxide, and alkyl radicals. Especially, the extracts exhibited the highest scavenging activity on hydroxyl radical, which is deemed of the strongest radical. In addition, we also evaluated the protective effects of Myelophycus simplex extract on 3.5% alcohol-induced damage (oxidative stress) in normal liver cells. The Myelophycus simplex extract inhibited productions of reactive oxygen species (ROS), and cell death against alcohol-induced liver cell damage. It was presumed that the Myelophycus simplex extract was involved in regulation of apoptosis-related pathway in the cell environments. These results indicate that Myelophycus simplex extract possess antioxidative activity on liver cells.
Highlights
Free radicals are highly related to aging promotion, and recently, attempts to obtain antioxidants harmless to the human body from natural plants while enhancing the antioxidant enzyme system in vivo have been performed from various angles [1,2]
Hydroxyl radicals generated in the ferrous ion/hydrogen peroxide system were trapped by DMPO, forming a spin adduct detected by an ESR spectrometer
The alkyl radical spin adduct of 4-POBN/free radical was generated from AAPH, and a decrease in ESR signals was observed with the dose increment of extract
Summary
Free radicals are highly related to aging promotion, and recently, attempts to obtain antioxidants harmless to the human body from natural plants while enhancing the antioxidant enzyme system in vivo have been performed from various angles [1,2]. Natural antioxidants are mostly antioxidants of plant origin and are present in all parts of trees, bark, stems, leaves, fruits, roots, flowers, fruits, seeds, etc. These are mainly phenolic compounds that delay the formation of free radicals or an antioxidant by inhibiting activity [5,6,7]. Myelophycus simplex is a brown algae belonging to the broad seaweed family. It is a brown, needle-shaped, single-stranded, forming a bunch. Brown algae are known to contain the components of fucoidan and laminarin, which have anti-cancer and anti-inflammatory physiological activities [9,10]. Research on the functionality of Myelophycus simplex has been rarely conducted except for studies on neuronal protective effects [11]
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