Abstract
Thera are many severe diseases caused by infection with enveloped negative-stranded RNA viruses which could benefit significantly from antiviral therapy. These diseases include rabies caused by a rhabdovirus, Lassa fever, Argentinian and Bolivian hemorrhagic fevers caused by arenaviruses, Ebola and Marburg hemorrhagic fevers caused by Filoviridae, other hemorrhagic fevers associated with bunyavirus infections [Crimean-Congo hemorrhagic fever (CCHF), Rift valley fever and hemorrhagic fever with renal syndrome (HFRS)], as well as many of the togavirus diseases such as encephalitis, Yellow fever and Dengue fever. The status of antiviral therapy differs for each of these infections, but with few exceptions little clinical trial data exist. The purpose of this review will be to summarize the relevant data for antiviral therapy of these diseases with special emphasis on those human RNA virus infections already known to respond to antiviral therapy in clinical trials.
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