Abstract

The purpose of the present work was to study antiviral activity and the structure of two medical preparations (collargol and protargol) containing silver particles and clusters. Optical properties, particle size distribution and oxidation state of silver particles were investigated by means of the diffuse reflectance electron spectroscopy, high resolution electron spectroscopy, small angle x-ray scattering, auger-electron spectroscopy and x-ray diffraction. Investigation of both preparations in vitro showed that antiviral activity calculated per one gram of silver for collargol is higher than that for one protargol by coefficient ca. 1.5. These two preparations showed significant difference in particle size distribution and small cluster contribution. In protargol, small silver clusters with size ca. 1 nm predominate, while in collargol the size of predominant particles is essentially higher. In collargol, silver is predominantly in metallic state while in protargol either in metallic or oxidized states. Fast oxidation of small silver clusters in protargol was observed in aqueous solution. It is suggested that the silver clusters do not play the leading role in antiviral action of the preparations. Possible mechanism of antiviral activity of the silver particles is discussed.

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