Abstract

AbstractExtracts of Seaweeds, seagrasses, and mangroves were screened in vitro against Semliki forest virus (SFV) on Vero cells. Anti-SFV activity was determined on the basis of inhibition of cytopathic effect (CPE). Of the 50 extracts tested, nine were found effective by inhibiting CPE from 55 to 95%. Ceriops decandra (Griff.) W. Theobald leaf showed the higher activity in vitro. The extracts effective in the in vitro assay were tested in vivo and their activity was determined on the basis of mortality and average survival time. Two extracts, Cheilosporum spectabile and Rhizophora mucronata Lam. (Rhizophoraceae), were found to be effective in protecting mice from lethal SFV infection.

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