Abstract
Background/Aim: Chronic hepatitis B (CHB) is a major health concern in terms of high prevalence, as well as restricted and costly health-care resources in India. The objective was to evaluate the antiviral effect of herbal drugs, Saussurea lappa and Artemisia absinthium against hepatitis B virus (HBV) in the management of CHB and to collect data to warrant further clinical trials. Materials and Methods: In an open prospective single-arm study, we assigned thirty patients with HBeAg-negative or positive CHB to receive decoction of S. lappa, 15 mL in the morning, and decoction of A. absinthium, 15 mL in the evening once daily empty stomach for 12 weeks. Test drug was evaluated for its efficacy in loss of HBsAg and HBeAg, plasma HBV DNA level of Abbreviations Used: CHB: Chronic hepatitis B, HBV: Hepatitis B virus, S. lappa: Saussurea lappa, A. absinthium: Artemisia absinthium, HBsAg: Hepatitis B surface antigen, HBeAg: Hepatitis B e antigen, HBV DNA: Hepatitis B deoxyribonucleic acid, cVR: Complete virologic response, ALT: Alanine aminotransferase.
Published Version
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