Antiviral compounds investigated by solid-state deuterium NMR spectroscopy

Abstract

Antiviral compounds like rimantadine, amantadine, and their derivatives are effective combatants against diseases such as influenza and dyskinesia. Characterization of structure and dynamics of these molecules is essential for understanding their antiviral activity. Here we conducted solid-state 2H NMR relaxometry to elucidate the internal dynamics and structural restraints of these compounds in the solid state. Quadrupolar-echo based relaxometry experiments were performed on powdered samples of deuterated rimantadine and amantadine.