Abstract
IT has been shown repeatedly that preparations of mouse interferon inhibit the growth of mouse cells in vitro1–4 In addition to inducing the antiviral state and inhibiting cell growth, preparations of mouse interferon stimulate interferon production by priming5, enhance phagocytic activity6, and potentiate in cells the toxic effect of double-strand ed RNA7. All attempts with preparations of mouse interferon to separate the antiviral activity from the non-antiviral activities have been unsuccessful3,5,8. With human interferon few experiments have been reported, although the data available indicate inhibition of growth by preparations of human leukocyte interferon9–11. It has been claimed that the antiviral and cell growth inhibitory activities of human leukocyte interferon reside in different molecules and can be separated from each other by certain methods of fractionation12. In a more recent report13, however, separation of the two activities could not be demonstrated even in drastic denaturing conditions. I have shown that both the antiviral and the cell growth inhibitory activity of human fibroblast interferon reside in the same glycoprotein.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.