Abstract
The article presents data on the antiviral activity of ethanol and aqueous extracts isolated from the herb plants Dracocephalum nutans, Glechoma hederacea, Melissa officinalis, Berteroa incana, Aegopodium podagraria, and Veronica longifolia against the A/Aichi/2/68 (H3N2) and A/chicken/ Kurgan/05/2005 (H5N1) subtypes of influenza A virus (IAV) in MDCK cell culture. It was found that the ethanol extracts of Glechoma hederacea, Berteroa incana, and Aegopodium podagraria have the antiviral activity in vitro in MDCK cell culture against H3N2 subtype of IAV. The aqueous extracts of Glechoma hederacea, Melissa officinalis, Aegopodium podagraria, and Veronica longifolia and ethanol extracts of Berteroa incana and Veronica longifolia are active against H5N1 subtype of IAV. None of the extracts of Dracocephalum nutans showed significant activity against the studied subtypes. The greatest efficiency was shown by the ethanol extract of Aegopodium podagraria against the H5N1 subtype and aqueous extracts from Glechoma hederacea and Melissa officinalis.against the H3N2 subtype. The ethanol extract of Berteroa incana has a high activity against both IAV subtypes, which makes this sample the most promising for creating new drugs for the prevention and treatment of influenza virus.
Highlights
The creation of new effective antiviral drugs is one of the most important and urgent tasks of modern medical science because of the accelerated evolution of viruses and almost no efficiency of antibiotics for viral diseases.From ancient times to the present day, mankind uses plants to treat various diseases
The goal of the work was to study the antiviral activity of extracts of Siberian plants Dracocephalum nutans, Glechoma hederacea, Melissa officinalis, Berteroa incana, Aegopodium podagraria, and Veronica longifolia against the H3N2 and H5N1 subtypes of influenza A virus
We studied the inhibition of reproduction of the A/chicken/Kurgan/05/2005 (H5N1) and A/Aichi/2/68 (H3N2) influenza A virus (IAV) subtypes in the Madin-Darby Canine Kidney (MDCK) cell culture under the action of ethanol and aqueous extracts of Dracocephalum nutans, Glechoma hederacea, Melissa officinalis, Berteroa incana, Aegopodium podagraria, and Veronica longifolia
Summary
The creation of new effective antiviral drugs is one of the most important and urgent tasks of modern medical science because of the accelerated evolution of viruses and almost no efficiency of antibiotics for viral diseases.From ancient times to the present day, mankind uses plants to treat various diseases. The creation of new effective antiviral drugs is one of the most important and urgent tasks of modern medical science because of the accelerated evolution of viruses and almost no efficiency of antibiotics for viral diseases. Herbal preparations have low toxicity, a wide range of biological effects on the body, and minimum side effects compared to synthetic drugs. Some studies confirm an antiviral effect of both extraction preparations and individual plant substances. Our previous research has proved that extracts of plants, such as Alchemilla vulgaris, Agrimonia pilosa, Geum rivale, Spiraea salicifolia, Lythrum virgatum, Veronica krylovii, Monarda fistulosa, and Salvia officinalis show the in vitro antiviral activity against influenza virus, herpes simplex virus type 1 and 2, and orthopoxviruses (smallpox and mouse pox viruses) [1,2,3,4,5,6]
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