Abstract
This study was carried out as a preliminary investigation into selected medicinal plants of Nigeria with the aim of discovering and developing a drug with anti - measles virus activity as an alternative measure in disease control. Ten parts of seven plants ( Diospyros barteri leaf, Xylopia aethiopica leaf and stem bark, Picralima nitida stem, Cajanus cajan, Argemone Mexicana, Morinda lucida, Uvaria chamae leaf, stem and root bark) were dried, powdered and extracte d by cold maceration using absolute methanol, and maximum non - toxic dose (MNTD) of each extract to Vero cell was determined. The cytotoxic activity and ability of extracts to inhibit viral - induced cytopathic effect (CPE) in tissue culture were evaluated th ree days post - inoculation and incubation, by 3 - (4,5 Dimethylthiazol - 2 - yl) - 2,5 - diphenyltetrazolium bromide (MTT) colorimetric assay. Cytotoxic concentration at 50% (CC 50 ) and inhibitory concentration at 50% (IC 50 ) were determined using graphpad prism, and s elective index (SI) was calculated as ratio of CC 50 to IC 50 . Out of the ten plant extracts screened, Xylopia aethiopica leaf extract with IC 50 of 1.248 µg/mL, Uvaria chamae root and
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