Abstract
Interferons are a group of proteins produced by eucaryotic cells when they are stimulated by virus infection, double-stranded RNA and various other inducers. Cells, when treated with interferons, exhibit a number of responses, the principal action of interest in this review being the establishment of virus resistance. There are however a number of other responses that have been described, such as inhibition of non-viral agents; priming; blocking; cell-multiplication-inhibition; toxicity enhancement; enhanced synthetic activities; surface alteration; enhanced immunolysis; enhanced phagocytosis and various immune modulations. In this survey we will first discuss the antiviral action of interferon both in vitro and in vivo and describe the non-antiviral activities, as these are likely to contribute to virus resistance mechanisms in the animal.
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