Antiurolithiatic Activity of Pascopyrum smithii in a Polyherbal Formulation Inhibition of Calcium Oxalate Crystallization on Urolithiasis Induced Rats

Abstract

The research was aimed to “To formulate a polyherbal formulation of Pascopyrum smithii for Antiurolithiatic activity on Calcium Oxalate Induced Urolithiasis in Rats”Urolithiasis is defined as the presence of one or more stones at any point within the urinary tract. It is the third most common urinary tract disease; the others are frequent urinary tract infections and benign prostatic hyperplasia. The global incidence of urolithiasis is quite high and, despite enormous progress in the field of medicine, there is no truly satisfactory medication available for the treatment of kidney stones. Most patients still have to proceed for surgery to get rid of this painful disease. Hyperoxaluria is the main trigger for urolithiasisThe present study is to formulate an ayurvedic capsule for treatment of urolithiasis. And to study the role of Pascopyrum smithii in preventing and treating kidney stones and to further explore the effective metabolites from the crude extract.The formulated capsules are evaluated as per WHO guidelines and also performed pharmacological activity.