Abstract
ABSTRACT The antilithiatic and diuretic activity of 7-hydroxy-2′,4′,5′-trimethoxyisoflavone and 7-hydroxy-4′-methoxyisoflavone, isolated in aqueous extracts of the heartwood of Eysenhardtia polystachya, was tested in rats by observing calculus formation (experimentally induced by implantation of a zinc disc in the urinary bladder) and urine production. A significant decrease in urinary stone size was observed in animals treated with the compounds as compared with animals in control groups. The compounds also increased 24 h urine volume in rats as compared with the control animals not receiving the test compounds.
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