Abstract
Peptic ulcer disease is one of the most prevalent gastrointestinal disorders causing tremendous human suffering worldwide. The present study was designed to evaluate the antiulcerogenic activity of the methanol and solvent stem bark fractions (hexane, ethyl acetate and butanol) and elucidate their possible antiulcerogenic mechanisms. The antiulcerogenic mechanisms were investigated by estimation of Superoxide dismutase (SOD), Glutathione (GSH), Catalase (CAT), Vitamins A, C and E, Malondialdehyde (MDA) and involvement of KATp channel. Pretreatment with the methanol extract and solvent fractions produce significant reductions in ulcer index in a dose dependent manner. Ethylacetate fraction (EtyAc) showed the highest antiulcer activity. Elevated MDA and decreased levels of SOD, GSH, CAT, Vitamin A, C and E observed in ulcer control groups were significantly decreased and increased respectively in the EtyAc fraction treated groups. Antiulcer activity of the EtyAc fraction was blocked upon coadministration with glibenclamide; a KATp channel blocker. The stem bark extract of Lannea acida possess antiulcerogenic activity and the mechanisms seems to involve antioxidant activity and KATp channel opening.
Highlights
Peptic ulcer disease (PUD) is a problem of the gastrointestinal tract characterized by a break in the normal gastric mucosa integrity secondary to gastric acid and pepsin secretion[1]
The treatment groups were pretreated with the Ethylacetate fraction (EtyAc) fraction
The results showed that rats administered with ethanol had marked significant (p
Summary
Peptic ulcer disease (PUD) is a problem of the gastrointestinal tract characterized by a break in the normal gastric mucosa integrity secondary to gastric acid and pepsin secretion[1]. It represents a serious and growing health problem in the whole world[2]. During the last two decades, the use of plants for the prevention, treatment and/or management of PUD has been advocated. This is due to several reasons, namely, orthodox drugs provoke many adverse effects, perceived effectiveness, affordability, ease of accessibility and safety of medicinal plants. The present study is designed to evaluate the antiulcerogenic effect of stem bark extract and solvent fractions of L. acida on ethanol induced mucosal injury in albino rats
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