Antiulcer effects of the methanolic root extracts of Paulownia elongata on indomethacin-induced peptic ulcer in male albino rats

Abstract

Medicinal plants have been the basis of treatment of various diseases in African traditional medicine as well as other forms of treatment from diverse cultures of the world. The aim of this study is to evaluate the Antiulcer Effects of the Ethanol Root Extracts of Paulownia elongata on Indomethacin-Induced Peptic Ulcer in Male Albino Rats. A total of sixteen (20) male albino rats gotten from the HEMA animal Farm, Federal Housing Estate Bajabure Gerie, ulcer was induced by administration of indomethacin (30 mg/kg, orally, Clinical isolates of four bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Clostridium Bolulinum and Escherichia coli). The well method of the agar dilution was used to determine the antibacterial activity of the plant extracts. Were used for the antibacterial evaluation, and Gas Chromatography-Mass Spectrometry (GC-MS) analysis was used for phytochemical profiling. The study determined the phytochemical profile of methanol extracts of Paulownia elongate roots using GC-MS as displayed 20 chemical constituents, the antibacterial potential of the roots extract showed higher activity at 300 mg/kg/bwt with 18.12 + 0.9 mm on Salmonella typhi and at 400 mg/kg/bwt with inhibition rate 20.14+ 0.0 mm on Klebsiella pneumonia. The anti-ulcer potential was observed higher at 400 mg/kg/bwt in group 7 with potential of 87.71%. This activity of the crude roots extract was possible as a result of the chemical constituent observed. Thus this extract should be used as an agents to cutile diseases such as anti-microbials, anti-ulcer and well as diseases as cancer, HIV in the near feature with more research to isolate the active compounds.