Abstract
In the present study effort has been made to establish the antiulcer activity of Saraca asoca (Roxb.), De Wild (family-Caesalpinaceae) stem bark hydroalcoholic-extract using ethanol induced ulceration model in albino rats, because no systematic study has been reported for its antiulcer activity. The effect of hydro-alcoholic extract (60:40) of S. asoca bark was investigated by carrying out an acute toxicity study in albino rats to evaluate the antiulcerogenic activity by using ethanol induced gastric ulcer model compared with omeprazole as standard drug. The preliminary photochemical screening of this medicinal plant identified the presence of important secondary metabolites like flavonoids and tannins. Acute toxicity study did not manifest any toxicological signs in rats. Oral administration of absolute ethanol (99.5 %, 5 mL kg -1, p.o.) produced significant ulcers index (41.00 ± 1.75) in the control group. Standard drug omeprazole (40 mL kg -1, p.o.) produced ulcer index (12.17 ± 0.74). Ulcer index (24.17 ± 1.40) is significantly (p<0.001) protected by hydro-alcoholic extract of S. asoca (stem bark) at a dose of 200 mL kg -1, p.o. The present finding suggests that hydro-alcoholic extract of S. asoca (stem bark) promotes ulcer protection activity.
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