Abstract
Objective: To evaluate the curative protects activity of electrohomeopathic drug Cancerous15 (C15) against Indomethacin (IND)-induced gastric ulcer in albino rats. None of the data have been reported on antiulcer activity of C15 drug. Hence, the present study focuses on the scientific investigation of antiulcer activity of C15 against Indomethacin-induced peptic ulceration of rat models.
 Methods: A total number of 35 albino rats were divided into five groups equally. Pure water was given to Group 1 (normal). IND was given orally to Group 2 (ulcerated control). Cancerous15 third dilution was given to Group 3. IND was given to Group 4 and Group 5 animals, thereafter pretreatment with Esomeprazole (ESM) and C15-third dilution, respectively. The pretreatments were treated in each day’s interval for 21 days before IND administration. There was provision of food and water throughout the experimental period. On the 23rd day, the stomachs of the sacrificed rats were removed, and (1) ulcer index, (2) percentage of ulcer inhibition, (3) gastric volume, (4) pH, (5) pepsin activity, (6) mucin content, (7) malondialdehyde (MDA) concentration, and (8) stearidonic acid activity were studied.
 Results: The pre-treated animals with ESM and C15 shown as significantly decreases in ulcer index, gastric volume, pepsin activity and MDA concentration, and significant increase in the percentage ulcer inhibition, pH value, mucin content, and superoxide dismutase activity concentration in comparison to ulcer-induced rats.
 Conclusion: The study shows the significant ulcer protective activity of the C15 drug against IND-induced peptic ulceration in rats.
Highlights
Electrohomeopathy an alternate medical system is widely practiced in many countries by the practioners since 1865
The several effects of Cancerous 15 (C15) have been shown antiulcerative parameters include (i) the ulcer index, (ii) percentage of inhibition against lesions, (iii) decrease in gastric volume, (iv) increase in gastric pH, (v) decrease in pepsin activity, (vi) increase in mucin content, (vii) decreased gastric malondialdehyde (MDA) level, (viii) increased in superoxide dismutase (SOD) activity within the experimental animals depicted in Figs. 1-8, respectively
It was found that the Group 4 and Group 5 animals show a significant decrease in ulcer index, gastric volume, pepsin activity, and MDA concentration in comparison to Group 2 animals, and simultaneously, there is a significant increase in percentage ulcer inhibition, pH value, mucin content, and SOD activity concentration in compared to Group 2 animals
Summary
Electrohomeopathy an alternate medical system is widely practiced in many countries by the practioners since 1865. All drugs are extracted from plants by cohobation method. An effort is made to prove the efficacy of one of the drug scientifically. In view of the treatment of peptic ulcer in clinical practice, it is found that the herbal drugs and alternative medications are effective and even more reliable in comparison to proton-pump inhibitor and H2 blocker as the formers are less toxic, cheap, and not involving in any type of drug interaction. Electrohomeopathic drug Cancerous 15 (C15) belongs to the present category. Local elctrohomeopathy practitioners are widely using electrohomeopathic drug C15 in the treatment of peptic ulcer and become successful
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