ANTIULCER ACTIVITY OF AQUEOUS EXTRACT OF FRESH LEAF OF BRASSICA OLERACEAE LINN. VAR. ACEPHALA (D.C) ALEF) (BRASSICACEAE)

Abstract

Brassica o leraceae (BOL) is the common cabbage and a familiar garden plant, widely used as spice all over the world. Cabbage is an excellent sou rce of Vitamin C and has been widely employed locally to treat acute inflammation and peptic ulcers. The present study aim ed at evaluating the anti ulcer activity of Brassica oleraceae , while identifying the phytoconstituents responsible for the observed effects and exploring some of the possible mechanisms of its anti ulcer activity, using standard laboratory procedures. Dos es of 100, 300 and 750 mg / kg of Brassica oleraceae were separately administered to groups of overnight fasted rats, with appropriate standard drugs using Ethanol / HCl, Indomethacin and Cysteamine models to explore anti ulcer property of BOL on the stoma ch and duodenum respectively. The extract in a dose dependent fashion, offered better protection against the ulcerogens in the gastric ulcer models, when compared with the positive control groups. However, the smallest dose of 100 mg / kg recorded the hig hest percentage protection in the cysteamine group. Up to 1200 mg / kg i.p and 10,000 mg / kg oral doses of Brassica oleraceae did not produce any mortality in mice. Phytochemical constituents identified included alkaloids, tannins, cardiac glycosides, fla vonoids, phlobatannins, anthraquinones and saponins. The pH was 8.5. The present study ha s validated the local use of Brassica oleraceae in the treatment of peptic ulcer and the speculated mechanisms of action could be through acid neutralization, cytoprot ection and antioxidation by flavonoids.