Abstract
A dimethyl-benz-dithionapthene-induced fibrosarcoma shows reduced transplantability in syngeneic Swiss mice when treated with Vibrio cholerae neuraminidase (VCN). Reduced transplantability of fibrosarcoma has also been observed if they are X-irradiated. Inoculation of VCN treated cells leads to the development of strong antitumour immunity, whereas comparable results are not obtained with X-irradiated cells. However, inoculation of cells treated with VCN followed by X-irradiation can also establish lasting antitumour immunity. It is suggested that ‘tumour vaccine’ produced in this way may be very effective for the immunotherapy of tumour.
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