Antitumour Activity of Methanolic Extract of Plumeria alba L. Leaves Against Dalton Lymphoma Ascites in Mice

Abstract

Purpose: To evaluate Plumeria alba leaves for antitumor activity against Ehrlich ascites carcinoma (EAC) and Dalton lymphoma ascites (DLA) bearing Swiss albino mice. Method: The antitumour activity of the methanolic extract of Plumeria alba leaves (MPA) was evaluated against EAC and DLA using in-vitro cytotoxic and mean survival time, a decrease in the tumour volume and viable cell count in the DLA tumour hosts. The animal was observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count, and differential cell count) following MPA treatment of the tumour bearing mice. Results: MPA was found to be cytotoxic in the invitro model. Intraperitoneal administration of MPA increased the survival time, dead cell count haematological parameters and solid tumour mass was also significantly reduced. Conclusion: MPA possesses significant antitumour activity. Keywords: Antitumour, cytotoxicity Plumeria alba L.