Abstract
From the methanolic extracts of solid callus cultures from two species of the closely related palaeotropical plant families Dioncophyllaceae and Ancistrocladaceae seven new natural naphthoquinones were isolated, dioncoquinones A ( 4) and B ( 5) from Triphyophyllum peltatum, and ancistroquinones B ( 6), C ( 7), D ( 9), E ( 10), and F ( 12) from Ancistrocladus abbreviatus. Their structures were elucidated by spectroscopic, chemical, and computational methods. Furthermore, the already known naphthoquinones plumbagin ( 2), droserone ( 3), malvone A ( 8), and nepenthone A ( 11) were found in the extract of A. abbreviatus. Dioncoquinones A ( 4) and B ( 5) showed good – and specific – activity against Leishmania major, while they were not active against other protozoic parasites. Moreover, treatment with 4 and 5 strongly induced apoptosis in human tumor cells derived from two different B cell malignancies, B cell lymphoma and multiple myeloma, without any significant toxicity towards normal peripheral mononuclear blood cells.
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