Abstract
The antitumor effect of indomethacin on Colon 26 was investigated in vivo and the telomerase activity in the tumor tissues was monitored under chronic indomethacin treatment. Tumor growth was significantly suppressed with indomethacin treatment compared to the controls. In addition, telomerase activity in the tumor tissues markedly declined in contrast to the telomerase activity in the testis and liver, which was not affected by indomethacin treatment. This is the first observation that indomethacin can suppress tumor growth in association with a preferential decrease in telomerase activity in tumor tissues. This study suggests a method to investigate the mechanism(s) of tumor suppression by indomethacin. Furthermore, this study suggests that telomerase activity in the tumor tissues might be a good index to estimate the effectiveness of antitumor agents.
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