Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods

Sihao Gu,Ling Li,Tong Zhang,Hai Huang,Bing Wang

doi:10.3390/molecules24162956

Abstract

Atractylodes macrocephala Koidz. has been used as an invigorating spleen drug for eliminating dampness and phlegm in China. According to recent researches, different processing methods may affect the drug efficacy, so we collected A. macrocephala from the Zhejiang Province, produced with different processing methods, crude A. macrocephala (CA) and bran-processed A. macrocephala (BA), then analyzed its essential oils (EOs) by GC/MS. The results showed 34 components representing 98.44% of the total EOs of CA were identified, and 46 components representing 98.02% of the total EOs of BA were identified. Atractylone is the main component in A. macrocephala. Compared with CA, BA has 46 detected compounds, 28 of which were identical, and 6 undetected compounds. Pharmacodynamic results revealed that the EOs of CA and atractylone exhibited more effective anticancer activity in HepG2, MCG803, and HCT-116 cells than the EOs of BA; while the EOs of BA exhibited simple antiviral effect on viruses H3N2, both the EOs and atractylone show anti-inflammatory activity by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in ANA-1 cells.

Highlights

Atractylodes macrocephala Koidz. (Baizhu in Chinese), a perennial herb from the Compositae family, is a drug commonly used in traditional Chinese medicine
It is believed that the essential oils (EOs) of crude A. macrocephala (CA), EOs of bran-processed A. macrocephala (BA), and atractylone have anti-inflammatory activity
It is believed that the EOs of CA, EOs of BA,7 and of 14 atractylone have anti-inflammatory activity

Summary

Introduction

Atractylodes macrocephala Koidz. (Baizhu in Chinese), a perennial herb from the Compositae family, is a drug commonly used in traditional Chinese medicine. (Baizhu in Chinese), a perennial herb from the Compositae family, is a drug commonly used in traditional Chinese medicine. It has been used as a food and medicinal herb in China for thousand years [1]. In China, A. macrocephala is mainly distributed in Zhejiang. Province which is known as one of authentic medicinal herbs “Zhebawei” [2]. Many components, such as essential oils (EOs), sesquiterpenoids, polysaccharides, amino acids, vitamins, resins, and other ingredients have been found in A. macrocephala up till recently [3,4]. A. macrocephala has many effects, such as strengthening the spleen, benefiting vital energy, eliminating dampness, hidroschesis, and soothing fetuses [5].

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Discussion

Conclusion