Abstract
ABSTRACT: We evaluated the effi ciency of 12 aqueous extracts obtained at three diff erent tempera-tures from four strains of culinary–medicinal Shiitake mushroom Lentinus edodes in protecting mice against the development of Ehrlich carcinoma. We observed fi rst that the strains Le 96/17 and Le 95/01 of L. edodes were more effi cient than JAB/k and Le 96/22 in increasing the survival time of tumor-bearing mice and that the temperature of 60 °C for extraction was more effi cient than 22 °C or 100 °C for the fi rst two strains. Groups of animals were then sacrifi ced following the treatments with the extract from Le 96/17 or Le 95/01 obtained at 60 °C and evaluated on the NK activity, the lymphoproliferative responsiveness of spleen cells to concanavalin A, and the specifi c antibody production. NK activity and proliferative response were not aff ected by the treatments, whereas the antitumor antibody response was enhanced by Le 95/01. Further analysis demonstrated that the extracts in vitro
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