Abstract
This study was designed to search the antitumor potential of Peganum harmala methanolic extracts and to evaluate their role in retardation the immunological side effects pre-and post-treatment which were carried out on 30 Albino male mice and included total and absolute count of leucocytes, micronucleus formation and phagocytic index of peritoneal cells. Our study showed that P. harmala derivatives have considerable antitumor activity with high efficacy in immobilization of the immunological side effects evoked following treatment with antitumor drug. In conclusion, P. harmala possess antitumor activity increases with concentrations increasing. Pre-treatment with these extracts exert higher retardation to the side effects than post-treatment.
Highlights
This study was designed to search the antitumor potential of Peganum harmala methanolic extracts and to evaluate their role in retardation the immunological side effects pre-and post-treatment which were carried out on 30 Albino male mice and included total and absolute count of leucocytes, micronucleus formation and phagocytic index of peritoneal cells
Cytotoxicity of P. harmala was screened on L20B was obtained from the Biotechnology Research Center/ Al-Nahrain
As shown in table (1), this crude extract of P. harmala has cytotoxic effect in the growth of L20B cell line starting at the concentration 125 μg/ml with high significance difference (P≤0.05) accompanied with increased cytotoxic effect toward the higher concentrations when compared with the negative control during this incubation period
Summary
This study was designed to search the antitumor potential of Peganum harmala methanolic extracts and to evaluate their role in retardation the immunological side effects pre-and post-treatment which were carried out on 30 Albino male mice and included total and absolute count of leucocytes, micronucleus formation and phagocytic index of peritoneal cells. The β-carboline alkaloids present in medicinal plants such as Peganum harmala have recently drawn attention due to their antitumor properties [3]. The pharmacologically active compounds of P. harmala are several alkaloids, which are found especially in the seeds and the roots These include β-carbolines such as: harmine, harmaline (identical with harmidine), harmalol and harman and quina-zoline derivatives: vasicine and vasicinone [4]. It is known that these alkaloids have a wide spectrum of neuropharmacological, psychopharmacological, and antitumor effects They have been traditionally used in oriental medicine for the treatment of various diseases including cancers [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
