Abstract
Six new triterpene glucosides, cumingianosides A-F (1-6) as well as trisnor- and a tetranortriterpene glucoside, cumindysosides A (7) and B (8), wiht a 14,18-cycloapoeuphane-type skeleton have been isolated from Dysoxylum cumingianum as antileukemic principles. The structures were established on the basis of chemical and spectroscopic evidence. Among them, compounds 1 and 3 exhibited potent selective cytotoxicity against MOLT-4 human leukemia cell with ED 50 of <0.00625 and <0.0045 μg/mL, respectively
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