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Abstract
The genus Xanthium (Asteraceae) is represented by limited number of species, which are distributed in all parts of the world. Some species were used in the traditional medicine for the treatment of basal cell carcinoma and different cancers and cold tumors.[1,2] In the course of our screening program for antiproliferative compounds in Asteraceae family found in Central and East Europe, extracts of X. italicum were evaluated. High cytotoxic activity was recorded for the lipophylic extract, thus this species was selected for bioassay-guided fractionation in order to identify the compounds responsible for the cytotoxic effect.
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