Abstract
The present work describes the design and preparation of lecithin microemulsion gels containing the aromatic tetra-benzamidine (TAPP-Br) and the antitumor evaluation of this topical formulation on nude mice xenografted with the highly tumorigenic cell line FH06T 1 -1, in comparison to the antitumor activity of TAPP-Br administered by intraperitoneal injections (0.5 mg/injection).After (trans) dermal treatment with 0.1 ml lecithin gels incorporating TAPP-Br (0.2 mg/ml), a reduction of in vivo tumor cell growth was observed. These results could be of great interest with a view to developing a releasing system useful for experimental chemotherapy of tumor lesions occurring at cutaneous or subcutaneous level.
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