Year-end Sale % OFF 
Abstract
Osteosarcoma is one of the malignant tumors that has a poor prognosis. In particular, relapsed or inoperable cases may require the development of new therapeutic approaches. Gene therapy is an innovative treatment for cancer, and is currently being investigated for osteosarcoma. Bax, one of the Bcl-2 family proteins, is a pro-apoptotic molecule that functions as a tumor suppressor, and Bax gene therapy has been investigated for various tumor cells. Gene transfer that is essential for the gene therapy is more efficient by mRNA lipofection than by plasmid DNA lipofection.1 Also as an effective mRNA-based cancer vaccine by systemic injection of MART1 mRNA has been reported in B16 melanoma.2 We examined the antitumor effect of the Bax mRNA transfected using a cationic liposome against human mandibular osteosarcoma cells in vitro, and further studied its antitumor effects in vivo comparing the differences between local administration and systemic administration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
