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Abstract
The biflavones 7,7-dimethyllanaraflavone (1), agathisflavone (2), and 7-methylagathisflavone (3) isolated from the leaves of Ouratea hexasperma and luxenchalcone (4) isolated from the leaves and branches of Luxemburgia octandra, as well as a mixture of 7,7-dimethyllanaraflavone and 7-methylagathisflavone, were assayed against HT-29 colon adenocarcinoma, NCl-H460 non-small cell lung carcinoma, MCF-7 breast cancer cell, OVCAR-3 ovarian adenocarcinoma cells, and RXF-393 renal cell carcinoma. The results show significant activities, particularly for 7,7-dimethyllanaraflavone (IC<sub> 50</sub> 0.77 ± 0.08, 2.42 ± 0.22, and 2.59 ± 0.32 mg/ml for NCl-H460, MCF-7, and OVCAR-3, respectively), and for 7-methylagathisflavone (IC<sub> 50</sub> values of 4 mg/ml). Luxenchalcone revealed significant cytotoxicity on the five cell lines tested.
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