Abstract
Atithrombotic therapy is required for the prevention and treatment of thromboembolic complications in specific pediatric patient populations. Recommendations for antithrombotic therapy in children have been loosely extrapolated from recommendations for adults because thromboembolic events in children were rare enough to hinder testing of specific therapeutic modalities, yet common enough to present significant management dilemmas that required therapeutic intervention. 1 Andrew M Marzinotto V Brooker L et al. Oral anticoagulant therapy in pediatric patients: a prospective study. Thromb Haemost. 1994; 71: 265-269 Crossref PubMed Google Scholar ,2 Massicotte P, Marzinotto V, Vegh P, et al. Home monitoring of warfarin therapy in children with a whole blood prothrombin time monitor. J Pediatr (in press) Google Scholar However, optimal prevention and treatment of children with thromboembolic complications likely differ from adults because of important ontogenic features of hemostasis that affect both the pathophysiology of the thrombotic processes and the response to antithrombotic agents.
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