Abstract
School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, KoreaReceived January 17, 2014, Accepted February 27, 2014In the course of our program to search for antithrombotic and anti-inflammatory agents from plants, twelvephenolics ( 1–12) were isolated from the stems of Parthenocissus tricuspidata . Their structures were elucidatedon the basis of spectroscopic (1D and 2D NMR, and MS) data analyses, and comparison with published data.At the concentration of 100 µg/mL, compounds 2, 4, 6 and 10 possessed potential effects on anti-bloodcoagulation, with inhibitory percentage of 216, 174, 148 and 225%, respectively; while aspirin used as positivecontrol showed 181% inhibition at the same concentration. Furthermore, the anti-inflammatory activity ofisolated compounds (1–12) was investigated on lipopolysaccharide (LPS)-induced murine macrophage cells(RAW264.7). Compounds 2, 4 and 6 also potential inhibited the production of nitric oxide, with IC
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