Antithiamine action of aminothiamine.

Abstract

1. Aminothiamine inhibits the growth of thiamine requiring L. fermenti by competing with thiamine, the inhibition index being 450 to 470.2. Aminothiamine inhibits competitively uptake of thiamine by resting cells of baker's yeast and L. fermenti.3. Aminothiamine inhibits baker's yeast thiamine kinase.4. As one of the sites of antithiamine action of aminothiamine on microorganism the competition between thiamine antagonist and thiamine in the process of permeation into cell membrane was discussed.