Abstract
Patients with antisynthetase antibody syndrome require long-term oral corticosteroids combined with immunosuppressants, which are prone to immune abnormalities and secondary infections. Varicella-zoster virus is a neurotropic virus that has long been latent in the posterior root of the spinal cord or the trigeminal ganglion. We describe a case of a case of antisynthetase antibody syndrome complicated by varicella-zoster virus infection of the nervous system, confirmed by next-generation sequencing of cerebrospinal fluid pathogens. This case aims to highlight that when a patient with an autoimmune disease and long-term use of immunosuppressants has an invasion of the cranial nerves by the herpes virus, performing imaging and CSF examinations (including etiology) is necessary to clarify the involvement of the central nervous system.
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