Abstract
INVESTIGATIONS on the concentration of antibodies in the cerebrospinal fluid in man and in animals have been made previously with varied results. Hektoen and Carlsson 1 found opsonins but no agglutinins or lysins in the cerebrospinal fluid of actively or passively immunized dogs. Becht and Greer 2 also failed to demonstrate lysins or agglutinins in the spinal fluid of these animals. Kafka, 3 however, found traces of hemolysins and bacterial agglutinins in the cerebrospinal fluid of immunized dogs. Starkenstein and Zitterbart 4 reported that only undiluted spinal fluid agglutinated typhoid bacilli in rabbits, although the serum titer was as high as 1: 10,000. Ransom 5 compared the titer for tetanus antitoxin in the serum with that in cerebrospinal fluid of a strongly immunized horse. He observed that the ratio in this animal was 100: 0.4. Freund 6 recorded that in 16 rabbits which he had immunized with dead typhoid bacteria
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