Abstract
BackgroundThe emergence of bacterial infections including those associated with Staphylococcus aureus causes a benefit of interest to medicinal plants as an effective means of control. The present study was designed to investigate the activities of 12 selected Cameroonian medicinal plants against S. aureus isolates.MethodsThe plant extracts were prepared by maceration in methanol at laboratory temperature. Qualitative phytochemical analysis was performed by chemical reaction methods. The broth microdilution method was used to evaluate the activities of plant extracts against 11 S. aureus clinical isolates.ResultsDacryodes edulis was found to have significant antibacterial activity on all the S. aureus isolates (MIC = 64–256 µg/ml). Occimum gratissimum revealed significant inhibitory activity on 9 of the 11 isolates while Commelina erecta and Spilanthes filicaulis revealed similar results on 6 of the 11 clinical isolates.ConclusionThe present findings showed that D. eduli, O. gratissimum,C. erecta and S. filicaulis possess interesting inhibitory properties against S. aureus species. These plants could therefore be good candidates to overcome infectious diseases associated with these microorganisms.
Highlights
The emergence of bacterial infections including those associated with Staphylococcus aureus causes a benefit of interest to medicinal plants as an effective means of control
The burden of S. aureus bacteremia, methicillin-resistant S. aureus bacteremia is due to the fact that, it is highly expensive in terms of cost and resource
The results revealed the presence of Phytochemical compounds including alkaloids, anthocyanins, anthraquinones, flavonoids, phenols, tannins and triterpenes (Table 2)
Summary
The emergence of bacterial infections including those associated with Staphylococcus aureus causes a benefit of interest to medicinal plants as an effective means of control. Infectious diseases are becoming a major cause of human and animal mortality and morbidity. This is further aggravated by the rapid development of multi-drug resistance, limited antibacterial spectrum and adverse effects of available antimicrobial agents [1]. Human pathogenic bacteria include amongst others Staphylococcus aureus; a major cause of bacteremia, associated with higher morbidity and mortality compared to other bacteremia-causing pathogens [2]. The investigation of certain indigenous plants for their antimicrobial properties may yield useful results. This has increased the attention and demand given to antimicrobials derived from the plants [5].
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